Get Applications of Biotechnology in Oncology PDF

By Kewal K. Jain

ISBN-10: 1461492440

ISBN-13: 9781461492443

ISBN-10: 1461492459

ISBN-13: 9781461492450

Applications of Biotechnology in Oncology collects key writings by means of Kewal ok. Jain at the most crucial contributions of biotechnology to melanoma examine, quite to the molecular prognosis of melanoma and drug supply in melanoma for custom-made administration of sufferers. fundamentals of varied “omics” applied sciences and their software in oncology are defined as oncogenomics and oncoproteomics. This precise quantity additionally explores molecular diagnostics, nanobiotechnology, telephone and gene cures, in addition to custom-made oncology. With nearly a thousand chosen references from contemporary literature in this subject and diverse tables and figures, Applications of Biotechnology in Oncology serves as a great reference for oncologists, scientists fascinated about examine on melanoma biology, and physicians in a variety of specialties who care for cancer.

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The heterogeneity of cancer cells with respect to their sensitivity to various death stimuli further emphasizes the need for additional death pathways in the therapeutic control of cell death. An understanding of the molecular control of alternative death pathways is beginning to emerge. Drugs or drug targets engaging caspase-independent death routines already exist, and an example is topoisomerase inhibitor camptothecin, which induces cathepsin-mediated apoptosis-like programmed cell death in hepatocellular carcinoma cells.

Centrosomes are abnormal in most aggressive carcinomas, and centrosome defects have been implicated in chromosome instability and loss of cell cycle control in invasive carcinoma. A significant fraction of precursor lesions to some of the most common human cancers had centrosome defects, including in situ carcinomas of the uterine cervix, prostate, and female breast. Moreover, centrosome defects occur together with mitotic spindle defects, chromosome instability, and high cytological grade. Because most preinvasive lesions are not uniformly mutant for p53, the development of centrosome defects does not appear to require abrogation of p53 function.

Self-cannibalization, called autophagy, occurs when a cell forms a membrane around a part of its cytoplasm or an organelle and then digests the contents, leaving a cavity. A cell that dies from autophagy is riddled with cavities. Cells normally employ autophagy temporarily to survive when nutrients are short, to recycle components to form new organelles, or to fend off viral or bacterial infection. In cancer research, there is evidence both that autophagy is a form of programmed cell death triggered to prevent the replication of damaged cells and that cancer cells in some instances employ it to survive attack.

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Applications of Biotechnology in Oncology by Kewal K. Jain


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