By Prasanthi Karna, Lily Yang (auth.), George G. Chen Dr, Paul B.S. Lai Dr (eds.)
The goal of this e-book is to supply details on apoptotic procedures inquisitive about significant neoplastic ailments and their translations into rising anti-cancer thoughts. The booklet is split into 15 chapters, each one of as a way to be excited about one specific melanoma (breast, bladder, cervical, colorectal, esophageal, gastric, laryngeal, liver, lung, nasopharyngeal, pancreatic, prostate, thyroid, leukaemia and cutaneous malignant melanoma). a few validated leaders within the box have significantly summarized the new discoveries touching on apoptosis in a selected melanoma and its capability for anti-cancer therapy. The booklet describes how the apoptosis performs a job within the particular carcinogen-induced mobile and molecular alterations in the course of the improvement of the melanoma, and severely discusses how the rising anti-cancer process could be outfitted via the usage of the explicit carcinogen-related apoptotic pathway. consequently, this booklet should be not just for laboratory-based molecular and mobile biologists and biochemists in melanoma learn but additionally for medical oncologists and people operating within the pharmaceutical and biotechnological industries.
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Additional resources for Apoptosis in Carcinogenesis and Chemotherapy: Apoptosis in cancer
Immunity 28:197–205 Hutcheson J, Scatizzi JC, Siddiqui AM, Haines GK, 3rd, Wu T, Li QZ, Davis LS, Mohan C, Perlman H (2008) Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity 28:206–217 Ibrahim SM, Ringel J, Schmidt C, Ringel B, Muller P, Koczan D, Thiesen HJ, Lohr M (2001) Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death. Pancreas 23:72–79 Igney FH, Krammer PH (2002) Death and anti-death: tumour resistance to apoptosis.
Yang References Abrams SI (2005) Positive and negative consequences of Fas/Fas ligand interactions in the antitumor response. Front Biosci 10:809–821 Adida C, Crotty PL, McGrath J, Berrebi D, Diebold J, Altieri DC (1998) Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am J Pathol 152:43–49 Aird KM, Ding X, Baras A, Wei J, Morse MA, Clay T, Lyerly HK, Devi GR (2008) Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression.
In murine embryonic stem (ES) cells, Oct-4 may be involved in survival of undifferentiated ES cells under stress by activating survivin gene expression through interaction with STAT3 since the apoptotic cell death is significantly increased in response to all stress situations 14 P. Karna and L. , 2008). Upregulation of survivin may also be one of the mechanisms for resistance to radiation in stem cells. It has been shown that treatment of primary BALB/c mouse mammary epithelial cells with clinically relevant doses of radiation enriches in normal progenitor cells.
Apoptosis in Carcinogenesis and Chemotherapy: Apoptosis in cancer by Prasanthi Karna, Lily Yang (auth.), George G. Chen Dr, Paul B.S. Lai Dr (eds.)