Get Antidiabetic Agents: Recent Advances in their Molecular and PDF

By H.P.T. Ammon, H.U. Häring, M. Kellerer, H. Laube, L. Mosthaf, E.J. Verspohl and M.A. Wahl (Eds.)

ISBN-10: 012013327X

ISBN-13: 9780120133277

Quantity 27, the 1st thematic quantity within the sequence, presents an outline of current wisdom in regards to the pharmacological and medical features of antidiabetic medicines. It goals to stimulate additional attention of attainable suggestions within the improvement of recent antidiabetic medicinal drugs.

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Additional info for Antidiabetic Agents: Recent Advances in their Molecular and Clinical Pharmacology

Example text

However, life CLINICAL ASPECTS OF DIABETES MELLITUS 21 expectancy is still considerably lower than in non-diabetics. As shown by Green et al. (1985) relative mortality in insulin-dependent diabetes decreases with increasing age at diagnosis and increases with increased duration of diabetes to a maximum at 15-25 years, after which it declines. Up to the age of 20 years, acute hypo- and hyper-glycaemic complications lead the diabetes-related death rates in Type-I diabetes. Between 20 and 40 years of age, renal failure (microangiopathy) and then coronary heart disease (macroangiopathy) are the most frequent causes of death.

Syndromes of extreme insulin resistance have revealed several important domains for ligand binding (Fig. 8). , 1988, 1989). , 1989) and specificity for ligand binding. , 1989). The 12 amino acids at the C-terminus of the a-subunit also appear to play MECHANISMS OF INSULIN ACTION 31 a role in insulin binding, since the presence of these amino acids (insulin receptor isoform B) results in a decrease in insulin affinity. The coupling of the a-subunit to the extracellular part of the/3-subunit occurs through disulphide bonds.

1990; Goldstein, 1992). At this level of the signal-transduction chain, serine phosphatases play an important role. A previously characterized enzyme in this context is protein phosphatase 1 (PP-1). Insulin stimulates a serine/threonine kinase which activates this protein phosphatase by serine phosphorylation (Goldstein, 1992).

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Antidiabetic Agents: Recent Advances in their Molecular and Clinical Pharmacology by H.P.T. Ammon, H.U. Häring, M. Kellerer, H. Laube, L. Mosthaf, E.J. Verspohl and M.A. Wahl (Eds.)


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