New PDF release: Antibody-Drug Conjugates

By Ingrid Sassoon, Véronique Blanc (auth.), Laurent Ducry (eds.)

ISBN-10: 1627035400

ISBN-13: 9781627035408

Antibody-drug conjugates (ADCs) signify a promising healing procedure for melanoma sufferers via combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic efficiency of chemotherapeutic medicines. In Antibody-Drug Conjugates, professional researchers supply targeted protocols for lots of of the foremost ADC concepts valuable for operating within the box. those chapters and methodologies are aimed toward the main initiatives essential to establish an appropriate aim, safely layout the mAb, the linker and the payload, in addition to to conjugate them in a reproducible and scalable type. Written within the hugely profitable Methods in Molecular Biology™ layout, those targeted chapters comprise the type of sensible implementation recommendation that promises caliber results.

Authoritative and well timed, Antibody-Drug Conjugates goals to extra force ADC improvement and therefore aid towards enhancing melanoma remedies of the future.

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Extra info for Antibody-Drug Conjugates

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Liu H, Moy P, Kim S et al (1997) Monoclonal antibodies to the extracellular domain of prostate specific membrane antigen also react with tumor vascular endothelium. Cancer Res 57:3629–3634, PMID 9288760 18. Silver DA, Pellicer I, Fair WR et al (1997) Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res 3:81–85, PMID 9815541 19. Chang SS, Reuter VE, Heston WD et al (1999) Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature.

In the same direction, the skinrelated AE observed for CDX-011 could be linked to the expression of gpNMB in normal melanocytes, which highlights skin as a particularly sensitive tissue to tubulin binders cytotoxics-ADC. In parallel, targets contribute to efficacy by their level and homogeneity of expression. AVE9633, targeting CD33 antigen, was stopped in phase I due to lack of efficacy signal, in part driven by the low expression of CD33 on AML blasts. T-DM1 ORR in clinic does not correlate with exposure but is clearly linked to the level of target expression on breast cancer cells, as ORR is higher in the group of patients whose tumors have confirmed HER2 overexpression.

J Med Chem 54:3606–3623 119. Moldenhauer G, Salnikov AV, L€ uttgau AV et al (2012) Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma. J Natl Cancer Inst 104:622–634 120. Kim KM, McDonagh CF, Westendorf L et al (2008) Anti-CD30 diabody–drug conjugates with potent antitumor activity. Mol Cancer Ther 7:2486–2497 121. Wittrup KD, Thurber GM, Schmidt MM et al (2012) Practical theoretic guidance for the design of tumor-targeting agents.

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Antibody-Drug Conjugates by Ingrid Sassoon, Véronique Blanc (auth.), Laurent Ducry (eds.)

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