By Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)
This quantity provides breakthroughs and strategies in affinity capillary electrophoresis to degree and be sure the physicochemical and thermodynamic parameters of drug compounds. It discusses ideas to discover and signify interactions to facilitate advancements in managed drug supply and focusing on.
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ISBN: 0781797667 | ISBN-13: 9780781797665 | eISBN: 1451158785 | eISBN-13: 9781451158786 | version: 6
Publication Date: March 2010
Publisher: Lippincott Williams & Wilkins
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Extra info for Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs)
If only one class of independent binding sites exists, then r= Db KA[Df ] = nи Ptotal 1 ϩ KA[Df ] (35) When the protein is the substrate, the drug is the ligand, and [SL] is the sum of all complexes, r then corresponds to Y. Provided the mobilities of the different protein–drug complexes are nearly the same, but different from the free drug, r and n can be calculated from the mobility data, analogously to Eq. (14): Ϫ S KA и[L] = nи SL Ϫ S 1 ϩ KA и[L] (36) A scatchard plot yields a straight line, as already shown in Fig.
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17. 18. 19. 20. 21. 43 MT Bowser, DDY Chen. Binding constants from rectangular hyperbolae. I: J Phys Chem 102:8063–8071, 1998; II: J Phys Chem 103:197–202, 1999. KL Rundlett, DW Armstrong. Methods for the determination of binding constants by capillary electrophoresis. Electrophoresis 22:1419–1427, 2001. KL Rundlett, DW Armstrong. Methods for estimation of binding constants by capillary electrophoresis. Electrophoresis 18:2194–2202, 1997. MT Bowser, DDY Chen. Higher-order equilibria and their effect on analyte migration behavior in capillary electrophoresis.
Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs) by Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)