Download e-book for iPad: Advances in Cancer Research, Vol. 84 by George Klein, George F. Vande Woude

By George Klein, George F. Vande Woude

ISBN-10: 012006684X

ISBN-13: 9780120066841

The Advances in melanoma examine sequence presents important details at the interesting and fast-moving box of melanoma learn. This quantity offers amazing and unique reports on quite a few subject matters, together with gene expression in inherited breast melanoma, multiparameter analyses of telephone cycle rules in tumorigenesis, Rho GTPases in transformation and metastasis, the myc oncogene, genetic requisites for the episomal upkeep of oncogenic herpesvirus genomes, therapy of Epstein-Barr virus-associated malignancies with particular T cells, the function of glycogen synthase kinase-3 in melanoma, continual immune activation and irritation within the pathogenesis of AIDS and melanoma, and molecular biology of Hodgkin's lymphoma. * Gene Expression in Inherited Breast melanoma * Multiparameter Analyses of CellCycle Regulatory Proteins in Human Breast melanoma: A Key to Definition of Separate Pathways in Tumorigenesis * Rho GTPases in Transformation and Metastasis * The myc Oncogene: Marvelously complicated * Genetic necessities for the Episomal upkeep of Oncogenic Herpevirus Genomes * therapy of Epstein-Barr Virus-Associated Malignancies with particular T Cells * function of Glycogen Synthase Kinase-3 in melanoma: law Wnts and different Signaling Pathways * power Immune Activation and irritation within the Pathogenesis of AIDS and melanoma * Molecular Biology of Hodgkin's Lymphoma

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Podratz, K. , and Hartmann, L. C. (1998). Ann. Intern. Med. 128, 896–899. Bochar, D. , Lane, W. , and Shiekhattar, R. (2000). Cell 102, 257–265. , and Vilo, J. (2000). FEBS Lett. 480, 17–24. Breast Cancer Linkage Consortium (1997). Lancet 349, 1505–1510. Breast Cancer Linkage Consortium (1999). J. Natl. Cancer Inst. 91, 1310–1316. Brown, M. , Grundy, W. , Sugnet, C. , Furey, T. , and Haussler, D. (2000). Proc. Natl. Acad. Sci. USA 97, 262–267. Cantor, S. , Bell, D. , Kass, E. , Wahrer, D. , Sgroi, D.

Sierk, A. , and Levine, A. J. (2001). Cancer Res. 61, 3124–3130. Olopade, O. , Lingjaerde, O. , and Trent, J. (2001). N. Engl. J. Med. 344, 2028–2029. 32 Ingrid A. Hedenfalk et al. Osborne, M. P. (1996). ” Lippincott-Raven, Philadelphia. , and Gusterson, B. (1998). Lancet 351, 1487. Pao, G. , and Verma, I. M. (2000). Proc. Natl. Acad. Sci. USA 97, 1020–1025. Park, J. , Irvine, R. , Koh, S. , Park, J. , Tilley, W. , Stallcup, M. , Press, M. , and Coetzee, G. A. (2000). Cancer Res. 60, 5946–5949.

2001). Interestingly, both p21 and p27 also have CDK stabilizing functions and seem to be needed for fully active CDK complexes (Dotto, 2000). , 1997). , 1998). In summary, the formation of various active CDK complexes that are needed for cells to pass the G1/S transition and S-phase represents a highly complex orchestration cascade of activating and inhibitory events offering a multitude of possibilities for aberrations in malignancies. The molecular mechanisms behind aberrations in G1/S regulatory proteins are numerous and include common activating and inactivating mechanism such as mutations, deletions, gene amplifications, and translocations as well as epigenetic phenomena such as silencing of promoters by hypermethylation of CpG island (Steeg and Zhou, 1998; Donnellan and Chetty, 1999; Rocco and Sidransky, 2001; Zheng and Lee, 2001).

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Advances in Cancer Research, Vol. 84 by George Klein, George F. Vande Woude


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