New PDF release: A Pharmacology Primer: Theory, Applications, and Methods

By Terry Kenakin

ISBN-10: 0123705991

ISBN-13: 9780123705990

The second one version will proceed this custom of higher getting ready researchers within the fundamentals of pharmacology. additionally, new human curiosity fabric together with historic proof in pharmacology may be additional. a brand new part on therapeutics may help readers establish with illnesses and medicines.

*Over 30 new figures and tables
*More human curiosity info to supply readers with old proof on pharmacology research
*New part on therapeutics to assist establish diseaes and drug treatments
*New part on new organic innovations proper to pharmacological learn (i.e., platforms biology)
*New research sections equipped with ASPET and different foreign pharmacology organizations
*New assurance of pharmacokinetics and drug disposition

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Additional info for A Pharmacology Primer: Theory, Applications, and Methods (2nd Edition)

Sample text

Not all full agonists are of equal efficacy; they only all saturate the system. In some cases, the stimulus-response characteristics of a system can be manipulated to provide a means to compare maximal responses of agonists (efficacy). Receptor desensitization can have differing overall effects on high- and low-efficacy agonists. All drug parameters are predicated on an accurate knowledge of the concentration of drug acting at the receptor. Errors in this independent variable negate all measures of dependent variables in the system.

The specific strengths and weaknesses inherent in both approaches are discussed in more detail in Chapters 4 and 5. As a preface to the consideration of these two major formats, a potential issue with both of them should be considered; namely, dissimulations between the concentrations of drugs added to the experimentally accessible receptor compartment and the actual concentration producing the effect. 9 Drug Concentration as an Independent Variable In pharmacological experiments the independent variable is drug concentration and the dependent (observed) variable is tissue response.

Messengers are briefly described. The overall efficiency of receptor coupling to these processes is defined as the stimulus-response capability of the cell. While individual stimulus-response pathways are extremely complicated, they all can be mathematically described with hyperbolic functions. The ability to reduce stimulus-response mechanisms to single monotonic functions allows relative cellular response to yield receptor-specific drug parameters. When the maximal stimulus-response capability of a given system is saturated by agonist stimulus, the agonist will be a full agonist (produce full system response).

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A Pharmacology Primer: Theory, Applications, and Methods (2nd Edition) by Terry Kenakin


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